21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase
21-in-1 Liposomal Nattokinase

Healthy Circulation

21 Named Ingredients

Healthy Blood Flow

10,800 FU Activity

Two Capsules Daily

Healthy Circulation

Healthy Blood Flow

10,800 FU Activity

21 Named Ingredients

Two Capsules Daily

4.88/5 | 50,000+ Happy Customers

21-in-1 Liposomal Nattokinase

Get your full-body circulation and daily vitality back with a high-potency 21-in-1 formula engineered to break down sluggish fibrin webs, relax constricted vessels, and deliver clean, effortless blood flow where you need it most.

Relieve heavy, tired legs so walking, climbing stairs, and standing on your feet feels light, comfortable, and effortless again

Warm cold hands and feet by opening up sluggish micro-vessels and delivering warm, oxygen-rich blood all the way to your fingers and toes

Promote smooth, unrestricted blood flow with 10,800 FU of active nattokinase that helps dissolve excess fibrin and keep arteries clear and flexible

Fuel cardiovascular stamina with CoQ10 and cellular nutrients so your heart pumps with ease and you stay energized throughout the day

  • No hidden subscription

  • 90 day guarantee

  • 100% natural
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“My feet were cold most evenings, and I was always searching for a better circulation formula. After a few weeks on two capsules a day, my evenings feel more comfortable, and I like knowing exactly what 10,800 FU means.”

★★★★★
Linda, 63 from Oregon
avatar Theo, 71 from Maine

“I did not want another mystery blend. The label shows the full serving, the activity, and the ingredients. Two capsules with breakfast is simple, and I feel more confident about the routine I’m following.”.

★★★★★
Theo, 71 from Maine
avatar Denise, 59 from Texas

“Long walks used to leave my legs feeling heavy. I started the two-capsule routine and stayed with it for the full bottle. My walks feel easier to stay with, and the 30-day supply makes consistency simple!”

★★★★★
Denise, 59 from Texas
avatar Paul, 68 from Kansas

“I was already taking CoQ10 and a few other supplements separately. This formula put the routine in one bottle, with nattokinase, bromelain, red yeast rice, and the vitamins listed clearly. That simplicity is what kept me taking it every day.”

★★★★★
Paul, 68 from Kansas

Can This Support Healthy Circulation? Here’s How

The cold feet. The heavy legs after sitting. The long search for a circulation formula that explains what is actually inside the bottle.

Choosing a daily circulation supplement should not mean choosing between one isolated ingredient and a crowded label that gives every ingredient a different promise.
Title

The Four Layers Behind Daily Circulation Support

1. Measured enzyme activity

Nattokinase is the lead active. The full serving provides 400 mg of nattokinase and 10,800 FU of activity.

 

2. Circulation and cardiovascular formula support

The formula includes red yeast rice extract, bromelain, vitamin C, vitamin K2, garlic, olive leaf, pomegranate, guggul, and fenugreek.

 

3. Cellular energy and nutritional support

CoQ10, niacin, vitamin B6, and choline bitartrate give the formula a nutritional and cellular-energy layer beyond a basic nattokinase capsule.

 

4. Liposomal delivery design

Liposomal describes the lipid-based delivery format used in the product. It is part of the formulation design, not a substitute for clear dosage, activity, or ingredient information.
Title

21 Ingredients. One Organized Circulation Formula.

Most single-ingredient products make you build the rest of the routine yourself.

This formula brings the lead nattokinase activity together with supporting enzymes, cardiovascular ingredients, nutritional support, and named botanicals.

It does not present 21 disconnected promises. It gives each part of the formula a clear place in the daily routine.
Title

What Are the 21 Ingredients?

Per full two-capsule serving: 

 

Ingredient Amount

 

Niacin (Vitamin B3) - 40 mg

Vitamin B6 - 2 mg

Vitamin C - 90 mg

Vitamin K2, as MK-7 - 160 mcg

Choline bitartrate - 100 mg

Nattokinase - 400 mg / 10,800 FU

Red yeast rice extract, 30:1 - 100 mg

Coenzyme Q10, ubiquinone - 100 mg

Bromelain, 2,400 GDU/g - 100 mg

Proprietary herbal blend - 300 mg

 

The 12 named herbs are turmeric, olive leaf, pomegranate, psyllium husk, artichoke, pumpkin seed, guggul, flax seed, fenugreek, garlic, black pepper, and green tea.

 

The total blend provides 300 mg per full serving. The individual amount of each herb is not separately listed because they are combined into one proprietary blend.
Title

Why people choose this formula instead of a basic capsule

The activity number is clear

10,800 FU applies to the full two-capsule serving.

The formula is organized

The page explains the role of the lead active, supporting ingredients, vitamins, and named herbs instead of dumping a long list on the label.

The amounts are visible

The formula shows the amounts for nattokinase, CoQ10, bromelain, red yeast rice, vitamins, choline, and the total herbal blend.

The delivery format is explained

Liposomal is presented as a formulation design, not as a substitute for dosage or proof.

The supply is easy to understand

Each bottle contains 60 capsules and 30 full servings. Choose one, two, or three bottles without signing up for a subscription
Title

Here’s How It Works

Days 1–7: Set the serving

Take two capsules daily as the full serving. That gives you the complete 10,800 FU activity amount.

Days 8–14: Keep the formula consistent

Continue with two capsules daily and keep the product in the same part of your routine each day.

Days 15–30: Complete the first bottle

One bottle contains 30 full servings. Continue with one bottle at a time, or choose two or three bottles for a longer supply.

Two bottles provide 60 full servings. Three bottles provide 90 full servings, free shipping, and the free Mushroom Gummies bonus.

50,000+ happy customers across all fifty states! 🇺🇸

The 8-Week Daily Circulation Routine

Weeks 1–2: (Build the routine)

Locking in the morning habit; the formula begins breaking down excess fibrin and supporting vascular cellular energy.

Weeks 2–3: (Notice the first shifts)

Feet and toes start feeling naturally warm under the sheets; calf stiffness eases after sitting.

Weeks 4–6: (Sharpen daily performance)

Walking, standing in line, and climbing stairs feel noticeably lighter and more comfortable without heavy legs holding you back.

Weeks 6–8: (Keep building momentum)

Consistent daily use creates a dependable foundation of warm extremities, light energized legs, and lasting cardiovascular vitality.

“CLINICAL TRIAL: 10,800 FU DAILY NATTOKINASE SUPPORTS ARTERIAL ELASTICITY AND BLOOD FLOW VELOCITY”
“In a landmark 12-month clinical study involving 1,062 human participants, daily supplementation with 10,800 FU of active nattokinase was evaluated for cardiovascular outcomes. The clinical data documented significant, measurable support for carotid artery wall health, healthy blood lipid parameters, and the natural clearance of arterial fibrin buildup.”
— Frontiers in Cardiovascular Medicine (12-Month Human Trial, n = 1,062)

21-in-1 Liposomal Nattokinase provides that exact 10,800 FU clinical activity level in every daily serving, surrounded by CoQ10, bromelain, red yeast rice, and 12 targeted botanicals in a protective liposomal delivery format.

10,800 FU clinical activity matching the landmark 12-month human trial dosage

Supports carotid arterial health and smooth, unrestricted blood flow velocity

Helps dissolve excess fibrin webs to relieve heavy legs and warm cold extremities

Fuels heart muscle energy with CoQ10 and essential cardiovascular antioxidants

Take two easy liposomal capsules each morning with water or breakfast

Here's How It Works:

1. SUPPORTS FIBRIN BREAKDOWN AND SMOOTH FLOW

Nattokinase (10,800 FU) and Bromelain target stubborn fibrin buildup that thickens blood and chokes off circulation to your legs, hands, and feet.

 

This is the flow layer of the formula.

2. RESTORES ARTERIAL ELASTICITY AND VESSEL TONE

Red Yeast Rice and Olive Leaf extract support clean, flexible arterial walls so oxygen-rich blood moves freely without resistance or strain.

 

This is the vessel elasticity layer of the formula.

3. FUELS CELLULAR HEART AND VASCULAR STAMINA

CoQ10 and Choline fuel mitochondrial energy production inside the heart muscle and vessel lining, keeping blood pumping strongly all day.

 

This is the fuel layer of the formula.

COMPLETES THE DAILY SYSTEM FOR TOTAL CIRCULATION

Turmeric, Pomegranate, Garlic, Green Tea, Artichoke, Guggul, and 6 botanicals complete the formula with support for micro-vessels, capillary flow, and whole-body vitality.

 

This is the comprehensive circulation layer.

The Formula Inside 21-in-1 Liposomal Nattokinase

JAPANESE NSK-SD® NATTOKINASE
(10,800 FU Per Serving)

a clinically studied fibrinolytic enzyme that dissolves stubborn fibrin protein mesh to restore unrestricted blood flow.

COENZYME Q10 (UBIQUINONE)
(100 mg Per Serving)

fuels myocardial mitochondria to sustain continuous all-day cardiac pumping stamina without stimulants.

BROMELAIN
(100 mg / 2,400 GDU/g)

pineapple-derived proteolytic enzyme working in synergy to accelerate fibrin breakdown and support leg comfort.

RED YEAST RICE EXTRACT (30:1)
(100 mg Per Serving)

standardized extract that promotes healthy blood lipid balance, clean arterial walls, and supple vascular flexibility.

VITAMIN K2 (MK-7) & VITAMIN C
(160 mcg / 90 mg Per Serving)

directs calcium away from arterial walls into bones while fueling vital collagen synthesis for supple blood vessel walls.

12-BOTANICAL CIRCULATION COMPLEX
(300 mg Per Serving)

targeted herbal blend defending micro-capillaries from oxidative damage and restoring warmth to cold extremities.

FAQs

What does Sky Nutrition 21-in-1 Liposomal Nattokinase support?

The formula is engineered to support full-body blood flow from head to toe. It helps dissolve stubborn fibrin protein buildup that thickens circulation, warms cold hands and feet by relaxing constricted peripheral capillaries, relieves heavy, leaden stiffness in the calves, restores supple arterial elasticity, and fuels all-day cardiac pumping stamina with CoQ10 and cellular nutrients.

How and when do I take it?

Take two vegetarian capsules each morning with a full glass of water, with or without breakfast. Making it part of your morning routine ensures active nattokinase and cellular CoQ10 circulate throughout your bloodstream, providing consistent 24-hour cardiovascular support and steady daily vitality.

When can I expect to feel results?

Most customers begin noticing initial shifts within 2 to 3 weeks, starting with warmth returning to cold toes and fingers in the evening and less stiffness in their calves after sitting. By weeks 4 to 6, walking, standing, and climbing stairs feel noticeably lighter and more comfortable. Results compound with consistent daily use over 8 weeks as arterial elasticity and micro-vessel flow become dependable and resilient.

What makes this different from basic single-ingredient nattokinase supplements?

Most circulation products use weak, unstandardized powders with only 2,000 FU that cannot dissolve stubborn fibrin webs, and their fragile enzymes get destroyed by stomach acid before reaching your blood. Sky Nutrition delivers three critical advantages:

  • Clinical Potency: 10,800 FU of authentic Japanese NSK-SD nattokinase per serving (over 5x the standard dose).
  • Liposomal Protection: Microscopic lipid shields protect delicate enzymes through harsh stomach acid for maximum bioavailable absorption.
  • 21-in-1 Synergy: Combines fibrinolytic nattokinase with bromelain, CoQ10, red yeast rice, vitamin K2 MK-7, and 12 targeted circulation botanicals, replacing a 5-bottle stack in two easy morning capsules.

What does FU mean, and is 10,800 FU per capsule or per serving?

FU stands for Fibrin Units. It is the gold-standard scientific measurement of an enzyme's active biological strength to dissolve and break down fibrin protein webs. Milligrams alone measure only dry powder weight, not enzyme power. The clinical 10,800 FU activity represents the full daily dose delivered in two capsules (5,400 FU per capsule).

What is liposomal delivery and why is it essential?

Enzymes like nattokinase and bromelain are sensitive proteins easily broken down by strong stomach hydrochloric acid. Liposomal delivery wraps these active compounds inside microscopic phospholipid bubbles that mirror your own cell membranes. This allows them to pass completely intact through your stomach and absorb directly into the bloodstream for maximum circulatory efficacy.

How does this formula specifically relieve cold feet and heavy legs?

Cold feet and heavy calves are the direct result of sluggish micro-circulation. Thick fibrin buildup creates resistance in small blood vessels, while constricted capillary walls starve extremities of oxygen and heat. Nattokinase breaks down the dense fibrin webs, while red yeast rice, olive leaf, and vasodilating botanicals relax vessel walls, allowing warm, nutrient-rich blood to rush freely down into your toes and lower legs.

Can I take this with prescription medications?

Sky Nutrition contains potent fibrinolytic enzymes and vascular nutrients (including nattokinase, bromelain, red yeast rice, CoQ10, and vitamin K2 MK-7). If you take prescription blood-thinning or antiplatelet drugs (such as warfarin, Eliquis, Plavix, or aspirin), blood pressure medications, or statins, or if you have scheduled surgery, please consult your prescribing physician before using this formula.

How many capsules are in each bottle, and what are the dietary details?

Each bottle contains 60 vegetarian capsules, providing 30 full two-capsule daily servings (a complete 1-month supply). The capsules are 100% vegetarian, non-GMO, gluten-free, dairy-free, and formulated without synthetic dyes, artificial fillers, or harsh binders.

Is this a one-time purchase or a recurring subscription?

All orders are 100% one-time purchases. You will never be enrolled in an unexpected subscription, and you will never be charged recurring fees or surprise monthly bills. You only order when you want more.

How fast is shipping, and how does the money-back guarantee work?

Orders are packed and dispatched within 24 to 48 business hours from our facility. Every order is protected by our risk-free guarantee: 30 days for 1 bottle, 60 days for 2 bottles, and 90 days for 3 bottles. If you do not experience warmer feet, lighter legs, and better daily stamina, simply contact our support team within your guarantee window for a prompt and courteous refund.